Breakthrough in DNA Synthesis Technology Drastically Cuts Time to Build New Genetic Sequences

Generative AI models like Evo 2 can design new DNA sequences at ultra-high speed, but physically building them in the lab has remained a slow and costly bottleneck.

The newly unveiled Sidewinder technology solves this problem by enabling dozens of genetic sequences to be assembled simultaneously in a single test tube.

• Precision innovation: While existing methods produced errors every 10 to 30 ligations, Sidewinder is accurate enough to allow just 1 error per 10 million assemblies.
• Speed and cost: Work that previously took over a month can now be completed in just a few days, using inexpensive raw materials.

Using Sidewinder, the research team successfully and flawlessly rebuilt a 12,500 base pair-long E. coli genetic sequence designed by Evo 2, with zero errors. This is expected to lay the groundwork for creating microorganisms with complex AI-designed biochemical pathways or artificial genomes.

The researchers who developed this technology founded a company called Genyro to commercialize it.