CASP-DREAM TAP Challenge Launches for TCR + Peptide-MHC Activation Prediction

·2026.11.07 05:22

Key point

The benchmark uses 5,800 labeled combinations where every test peptide is at least four edits away from any publicly reported TCR specificity.

New CASP-DREAM TAP Challenge requires models to predict T cell activation given TCR sequences and peptide-HLA inputs.
Benchmark consists of 5,800 labeled combinations scored by AUROC.
Test peptides are strictly unseen, defined as being at least four edits (Levenshtein distance) away from any peptide with publicly reported TCR specificity.
Training data options include the public VDJdb database and Harell Data's proprietary TCR datasets from Adaptive Biotechnologies.
Registration is open via Synapse.

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